13 Facts About Amlodipine

Amlodipine, sold under the brand name Norvasc among others, is a calcium channel blocker medication used to treat high blood pressure and coronary artery disease.

Amlodipine was patented in 1982, and approved for medical use in 1990.

Amlodipine is used in the management of hypertension and coronary artery disease in people with either stable angina or vasospastic angina and without heart failure.

Amlodipine can be given as a combination therapy with a variety of medications:.

Amlodipine-associated gingival overgrowth is a relatively common side effect with exposure to amlodipine.

Amlodipine is a long-acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes.

Amlodipine has an inhibitory effect on calcium influx in smooth muscle cells to inhibit contraction.

Amlodipine ends up significantly reducing total vascular resistance without decreasing cardiac output expressed by pressure-rate product and cardiac contractability in comparison with verapamil, a non-dihydropyridine.

Amlodipine is an angioselective calcium channel blocker and inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells which inhibits the contraction of cardiac muscle and vascular smooth muscle cells.

Amlodipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.

Amlodipine has been studied in healthy volunteers following oral administration of C-labelled drug.

Amlodipine is most often used to treat systemic hypertension in cats and dogs.

Amlodipine is used to treat congestive heart failure due to mitral valve regurgitation in dogs.