16 Facts About Ampicillin

Ampicillin is an antibiotic used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis.

Ampicillin was discovered in 1958 and came into commercial use in 1961.

Ampicillin used to be used to treat gonorrhea, but there are now too many strains resistant to penicillins.

Ampicillin is used to treat infections by many gram-positive and gram-negative bacteria.

Ampicillin can be administered by mouth, an intramuscular injection or by intravenous infusion.

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Ampicillin is contraindicated in those with a hypersensitivity to penicillins, as they can cause fatal anaphylactic reactions.

Ampicillin is comparatively less toxic than other antibiotics, and side effects are more likely in those who are sensitive to penicillins and those with a history of asthma or allergies.

Ampicillin reacts with probenecid and methotrexate to decrease renal excretion.

Ampicillin has been said to make oral contraceptives less effective, but this has been disputed.

Ampicillin is normally used to treat cholera and typhoid fever, lowering the immunological response that the body has to mount.

Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family.

Ampicillin is able to penetrate gram-positive and some gram-negative bacteria.

Ampicillin is well-absorbed from the GI tract, and reaches peak concentrations in one to two hours.

Ampicillin is distributed through most tissues, though it is concentrated in the liver and kidneys.

Ampicillin has been used extensively to treat bacterial infections since 1961.

Ampicillin demonstrated activity against gram-negative organisms such as H influenzae, coliforms, and Proteus spp.