16 Facts About Ampicillin

1.

Ampicillin is an antibiotic used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis.

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2.

Ampicillin was discovered in 1958 and came into commercial use in 1961.

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3.

Ampicillin used to be used to treat gonorrhea, but there are now too many strains resistant to penicillins.

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4.

Ampicillin is used to treat infections by many gram-positive and gram-negative bacteria.

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5.

Ampicillin can be administered by mouth, an intramuscular injection or by intravenous infusion.

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6.

Ampicillin is contraindicated in those with a hypersensitivity to penicillins, as they can cause fatal anaphylactic reactions.

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7.

Ampicillin is comparatively less toxic than other antibiotics, and side effects are more likely in those who are sensitive to penicillins and those with a history of asthma or allergies.

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8.

Ampicillin reacts with probenecid and methotrexate to decrease renal excretion.

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9.

Ampicillin has been said to make oral contraceptives less effective, but this has been disputed.

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10.

Ampicillin is normally used to treat cholera and typhoid fever, lowering the immunological response that the body has to mount.

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11.

Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family.

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12.

Ampicillin is able to penetrate gram-positive and some gram-negative bacteria.

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13.

Ampicillin is well-absorbed from the GI tract, and reaches peak concentrations in one to two hours.

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14.

Ampicillin is distributed through most tissues, though it is concentrated in the liver and kidneys.

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15.

Ampicillin has been used extensively to treat bacterial infections since 1961.

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16.

Ampicillin demonstrated activity against gram-negative organisms such as H influenzae, coliforms, and Proteus spp.

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