25 Facts About Archibald Garrod

Archibald Garrod served as Regius Professor of Medicine at the University of Oxford from 1920 to 1927.

Archibald Garrod discovered the abnormal uric acid metabolism associated with gout.

Archibald Garrod was educated at Marlborough College and Christ Church, University of Oxford.

Archibald Garrod performed poorly at Marlborough, struggling due to his lack of interest in classics, especially Latin prose and grammar.

Archibald Garrod graduated with a First-class Honours degree in natural science in 1878.

Archibald Garrod graduated in 1884 and then spent a year studying in Vienna at the general hospital, known as the Allgemeines Krankenhaus.

In 1919, his third son, Basil Rahere Archibald Garrod died, aged 21, in Cologne during the Spanish flu pandemic.

Archibald Garrod was a proponent of scientific research as the foundation of medical practice, and published on a variety of diseases and topics throughout his career, including An Introduction to the Use of the Laryngoscope and A Treatise on Rheumatism and Rheumatoid Arthritis.

Archibald Garrod helped found the Quarterly Journal of Medicine to provide a forum for more fundamental research into the processes of disease.

Archibald Garrod helped edit a pediatrics textbook, Diseases of Children, with Frederick Batten and James Hugh Thursfield.

Archibald Garrod is best known for his scientific study of inborn errors of metabolism.

Archibald Garrod developed an increasing interest in chemical pathology, and investigated urine chemistry as a reflection of systemic metabolism and disease.

Dr Archibald Garrod recorded the family history of the baby and kept tabs on the newborn's growth over the years.

Archibald Garrod quickly began seeking other patients with the same disorder and found forty cases and read up on the disorder, the first instance of which was noted in 1822.

Once the baby was born, Archibald Garrod had nurses closely inspecting the baby's diaper.

Archibald Garrod cites various case studies and compares alkaptonuria to albinism in how it's inherited.

Archibald Garrod studied the recurrence patterns in several families, realized it followed an autosomal recessive pattern of inheritance, and postulated that it was caused by a mutation in a gene encoding an enzyme involved in the metabolism of a class of compounds called alkapton.

Archibald Garrod published The Incidence of Alkaptonuria: a Study in Chemical Individuality in 1902.

Archibald Garrod described the nature of recessive inheritance of most enzyme defects.

Archibald Garrod expanded his metabolic studies to cover cystinuria, pentosuria, and albinism.

Archibald Garrod succeeded William Osler as Regius Professor of Medicine at Oxford.

Archibald Garrod was elected a Fellow of the Royal Society in 1910, was appointed to the Medical Research Council, and was made an honorary member of the American Association of Physicians, and of the Arztlicher Verein in Munich.

Archibald Garrod received honorary degrees from the universities of Aberdeen, Dublin, Glasgow, Malta, and Padua.

The Canadian Association of Centres for the Management of Hereditary Metabolic Diseases is commonly referred to as the Archibald Garrod Association to honor his contributions to the field of inborn errors of metabolism.

Archibald Garrod died at the Cambridge home of his daughter after a brief illness in 1936.