11 Facts About Atipamezole


Atipamezole has a very quick onset, usually waking an animal up within 5 to 10 minutes.

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Atipamezole is a veterinary drug whose prime purpose is to reverse the effects of the sedative dexmedetomidine.

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Atipamezole is licensed in the United States for intramuscular injection in dogs; it is used off-label in cats, rabbits, and farm animals such as horses and cows, as well as in zoo medicine for reptiles, armadillos, hippopotamuses, giraffes, okapi, and others.

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Atipamezole has been used as an antidote for various toxicities in dogs.

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Atipamezole is not recommended for animals that are pregnant, lactating, or slated for breeding.

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Atipamezole is a competitive antagonist at ?2-adrenergic receptors that competes with dexmedetomidine, an ?2-adrenergic receptors agonist.

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Atipamezole has a rapid onset: it reverses the decreased heart rate caused by sedation within three minutes.

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Atipamezole reaches maximum serum concentration within 10 minutes of IM administration.

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Atipamezole is distributed extensively to the tissues; at a particular time, concentrations in the brain reach two to three times the concentration in the plasma.

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Atipamezole undergoes heavy first-pass metabolism in the liver, which includes the glucuronidation at nitrogen during.

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Atipamezole has been researched in humans as a potential anti-Parkinsonian.

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