11 Facts About Atipamezole

Atipamezole has a very quick onset, usually waking an animal up within 5 to 10 minutes.

Atipamezole is a veterinary drug whose prime purpose is to reverse the effects of the sedative dexmedetomidine.

Atipamezole is licensed in the United States for intramuscular injection in dogs; it is used off-label in cats, rabbits, and farm animals such as horses and cows, as well as in zoo medicine for reptiles, armadillos, hippopotamuses, giraffes, okapi, and others.

Atipamezole has been used as an antidote for various toxicities in dogs.

Atipamezole is not recommended for animals that are pregnant, lactating, or slated for breeding.

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Atipamezole is a competitive antagonist at ?2-adrenergic receptors that competes with dexmedetomidine, an ?2-adrenergic receptors agonist.

Atipamezole has a rapid onset: it reverses the decreased heart rate caused by sedation within three minutes.

Atipamezole reaches maximum serum concentration within 10 minutes of IM administration.

Atipamezole is distributed extensively to the tissues; at a particular time, concentrations in the brain reach two to three times the concentration in the plasma.

Atipamezole undergoes heavy first-pass metabolism in the liver, which includes the glucuronidation at nitrogen during.

Atipamezole has been researched in humans as a potential anti-Parkinsonian.