13 Facts About Atropine


Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery.

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Atropine occurs naturally in a number of plants of the nightshade family, including deadly nightshade, Jimson weed, and mandrake.

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Atropine was previously included in international resuscitation guidelines for use in cardiac arrest associated with asystole and PEA, but was removed from these guidelines in 2010 due to a lack of evidence for its effectiveness.

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Atropine is useful in treating second-degree heart block Mobitz type 1, and third-degree heart block with a high Purkinje or AV-nodal escape rhythm.

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Atropine has been used in an effort to prevent a low heart rate during intubation of children; however, evidence does not support this use.

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Atropine is often used in conjunction with the oxime pralidoxime chloride.

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Atropine can be used to reduce the effect of the poisoning by blocking muscarinic acetylcholine receptors, which would otherwise be overstimulated, by excessive acetylcholine accumulation.

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Atropine has been observed to prevent or treat irinotecan induced acute diarrhea.

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Atropine is sometimes added to potentially addictive drugs, particularly antidiarrhea opioid drugs such as diphenoxylate or difenoxin, wherein the secretion-reducing effects of the atropine can aid the antidiarrhea effects.

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Atropine, a tropane alkaloid, is an enantiomeric mixture of d-hyoscyamine and l-hyoscyamine, with most of its physiological effects due to l-hyoscyamine.

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Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5.

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Atropine induces cycloplegia by paralyzing the ciliary muscles, whose action inhibits accommodation to allow accurate refraction in children, helps to relieve pain associated with iridocyclitis, and treats ciliary block glaucoma.

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Atropine can be synthesized by the reaction of tropine with tropic acid in the presence of hydrochloric acid.

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