1. Brenden Santi previously played for the Wests Tigers in the NRL.

1. Brenden Santi previously played for the Wests Tigers in the NRL.
Brenden Santi played his junior rugby league for the Chester Hill Hornets before being signed by the Canterbury-Bankstown Bulldogs.
In 2010, Brenden Santi was a part of the Canterbury-Bankstown Bulldogs' NYC squad but didn't play a game.
Brenden Santi joined the Wests Tigers and played for their NYC team from 2011 to 2013.
Brenden Santi played for the New South Wales Under 20s team, winning the Players' Player award.
Brenden Santi signed a two-year contract with the Parramatta Eels starting in 2014.
On 8 May 2014, Brenden Santi returned to the Wests Tigers mid-season on a contract to the end of 2015.
In round 25 of the 2014 NRL season, Brenden Santi made his NRL debut for the Tigers against the Canberra Raiders, in what was his only appearance for the season.
Brenden Santi played in 10 games in 2015, all from the bench.
Brenden Santi was not re-signed at the end of the season.
In 2018, Brenden Santi re-joined the Townsville Blackhawks, after spending the entire 2017 season playing for the Roosters' feeder club, the Wyong Roos, in the New South Wales Cup.
On 21 December 2019, Brenden Santi signed for the Newcastle Thunder for the 2020 League 1 season.
On 30 October 2020 it was announced that Brenden Santi would join Keighley Cougars for the 2021 season At the end of the 2021 season Brenden Santi signed a two-year contract extension with Keighley tying him to the club until the end of the 2023 season.
On 30 June 2023, Brenden Santi signed a contract to join York RLFC until the end of the 2023 season.
On 2 December 2024, Brenden Santi had re-signed with the club for the 2025 season.
Brenden Santi was named in the Italian squad for the 2021 Rugby League World Cup.