19 Facts About Bruce Beutler

Bruce Alan Beutler is an American immunologist and geneticist.

Bruce Beutler did so by identifying spontaneous mutations in the gene coding for mouse Toll-like receptor 4 in two unrelated strains of LPS-refractory mice and proving they were responsible for that phenotype.

Bruce Beutler is currently a Regental Professor and Director of the Center for the Genetics of Host Defense at the University of Texas Southwestern Medical Center in Dallas, Texas.

In 2012, Bruce Beutler was appointed as an Honorary Professor in the School of Biochemistry and Immunology at Trinity College Dublin.

Bruce Beutler further suggested that H-Y antigen, a minor histocompatibility protein encoded by a gene on the Y chromosome and absent in female mammals, was responsible for directing organogenesis of the indifferent gonad to form a testis.

In studying H-Y antigen, Bruce Beutler became conversant with immunology and mouse genetics during the 1970s.

Bruce Beutler worked in the laboratory of Abraham Braude, an expert in the biology of LPS.

Bruce Beutler received his secondary school education at Polytechnic School in Pasadena, California.

From 1981 to 1983 Bruce Beutler continued his medical training at the University of Texas Southwestern Medical Center in Dallas, Texas, as an intern in the Department of Internal Medicine, and as a resident in the Department of Neurology.

Bruce Beutler's focus on innate immunity began when he was a postdoctoral associate and later an assistant professor in the lab of Anthony Cerami at Rockefeller University.

Bruce Beutler demonstrated the existence of TNF receptors on most cell types, and correctly inferred the presence of two types of TNF receptor distinguished by their affinities, later cloned and designated p55 and p75 TNF receptors to denote their approximate molecular weights.

Bruce Beutler was recruited to a faculty position at UT Southwestern Medical Center and the Howard Hughes Medical Institute in 1986.

Bruce Beutler reasoned that in finding the LPS receptor, insight might be gained into the first molecular events that transpire upon an encounter between the host and microbial invaders.

Bruce Beutler invented a means of instantly identifying ENU-induced mutations that cause phenotypes.

Ernest Bruce Beutler was a hematologist and medical geneticist famed for his studies of G-6-PD deficiency, other hemolytic anemias, iron metabolism, glycolipid storage diseases, and leukemias, as well as his discovery of X chromosome inactivation.

Bruce Beutler's paternal grandmother, Kathe Beutler, was a pediatrician, trained at the Charite hospital in Berlin, earning her medical diploma in 1923.

Also a physician, Alfred Beutler was a cousin to the spectral physicist, Hans G Beutler, who worked at the Kaiser Wilhelm Institute and the University of Berlin before emigrating to the USA in 1936.

Bruce Beutler continued his work at the University of Chicago until his death.

Bruce Beutler married Barbara Beutler in 1980 and divorced in 1988.