10 Facts About Buprenorphine

Buprenorphine is an opioid used to treat opioid use disorder, acute pain, and chronic pain.

Buprenorphine affects different types of opioid receptors in different ways.

Buprenorphine was patented in 1965, and approved for medical use in the United States in 1981.

Buprenorphine treatment carries the risk of causing psychological or physiological dependencies.

Buprenorphine has been reported to possess these following pharmacological activities:.

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Buprenorphine is known to bind to with high affinity and antagonize the putative e-opioid receptor.

Buprenorphine is metabolized by the liver, via CYP3A4 isozymes of the cytochrome P450 enzyme system, into norbuprenorphine (by N-dealkylation).

Buprenorphine is a semisynthetic derivative of thebaine, and is fairly soluble in water, as its hydrochloride salt.

Buprenorphine has been introduced in most European countries as a transdermal formulation for the treatment of chronic pain not responding to nonopioids.

Buprenorphine has been used in the treatment of the neonatal abstinence syndrome, a condition in which newborns exposed to opioids during pregnancy demonstrate signs of withdrawal.