11 Facts About Burkitt's lymphoma

Burkitt Burkitt's lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center.

Burkitt Burkitt's lymphoma is uncommon in adults, in whom it has a worse prognosis.

Burkitt Burkitt's lymphoma can be divided into three main clinical variants: the endemic, the sporadic, and the immunodeficiency-associated variants.

Burkitt Burkitt's lymphoma is commonly associated with the infection of B cell lymphocytes with the EBV and in these cases is considered to be one form of the Epstein–Barr virus-associated lymphoproliferative diseases.

The endemic variant of Burkitt Burkitt's lymphoma is in almost all cases associated with EBV infection.

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The mutational landscape in Burkitt Burkitt's lymphoma has recently been found to differ between tumors with and without EBV infection, further strengthening the role of the virus in disease origin.

All types of Burkitt Burkitt's lymphoma are characterized by dysregulation of the c-myc gene by one of three chromosomal translocations.

Complete role of EBV in the pathogenesis of endemic Burkitt Burkitt's lymphoma is not completely elucidated, but it has been shown to cause DNA damage, dysfunction of telomeres, and genome instability.

Prognosis for Burkitt Burkitt's lymphoma is superior in children and increased age is a negative prognostic indicator.

The prognosis for Burkitt Burkitt's lymphoma can be better determined following staging utilizing imaging modalities such as positron emission tomography and computed tomography scans where tumor burden and invasion of the central nervous system have been found to indicate a poor prognosis.

The peak incidence for endemic Burkitt Burkitt's lymphoma is from ages 4 to 7 with an average age of 6 years.