20 Facts About Celiac disease

Coeliac disease or celiac disease is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye and barley.

Coeliac Celiac disease is caused by a reaction to gluten, a group of various proteins found in wheat and in other grains such as barley and rye.

Classic symptoms of untreated coeliac Celiac disease include pale, loose, or greasy stools, and weight loss or failure to gain weight.

Diarrhoea that is characteristic of coeliac Celiac disease is chronic, sometimes pale, of large volume, and abnormally foul in odor.

Coeliac Celiac disease leads to an increased risk of both adenocarcinoma and lymphoma of the small bowel .

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In many cases, it is unclear whether the gluten-induced bowel Celiac disease is a causative factor or whether these conditions share a common predisposition.

Coeliac Celiac disease is associated with several other medical conditions, many of which are autoimmune disorders: diabetes mellitus type 1, hypothyroidism, primary biliary cholangitis, microscopic colitis, gluten ataxia, psoriasis, vitiligo, autoimmune hepatitis, primary sclerosing cholangitis, and more.

Coeliac Celiac disease is caused by an inflammatory reaction to gliadins and glutenins found in wheat and to similar proteins found in the crops of the tribe Triticeae and to the tribe Aveneae .

Almost all people with coeliac Celiac disease have either the variant HLA-DQ2 allele or the HLA-DQ8 allele.

The reason these genes produce an increase in the risk of coeliac Celiac disease is that the receptors formed by these genes bind to gliadin peptides more tightly than other forms of the antigen-presenting receptor.

Avenin's toxicity in people with coeliac Celiac disease depends on the oat cultivar consumed, as prolamin genes, protein amino acid sequences, and the immunoreactivities of toxic prolamins vary among oat varieties.

Capsule endoscopy allows identification of typical mucosal changes observed in coeliac Celiac disease but has a lower sensitivity compared to regular endoscopy and histology.

Gastrointestinal and extraintestinal symptoms of people with non-coeliac gluten sensitivity can be similar to those of coeliac Celiac disease, and improve when gluten is removed from the diet, after coeliac Celiac disease and wheat allergy are reasonably excluded.

In untreated coeliac Celiac disease, these are often transient conditions derived from the intestinal damage.

Celiac disease regarded this as an affliction of the old and more commonly affecting women, explicitly excluding children.

Celiac disease noted their growth was retarded and that fat was better tolerated than carbohydrate.

The eponym Gee-Herter Celiac disease was sometimes used to acknowledge both contributions.

Celiac disease reported that once wheat was again available after the conflict, the mortality rate soared to previous levels.

Coeliac disease is the preferred spelling in British English, while celiac disease is typically used in North American English.

Attempts to modulate the immune response concerning coeliac Celiac disease are mostly still in phase I of clinical testing; one agent has been evaluated in a phase II clinical trial based on small-intestinal biopsies taken from people with coeliac Celiac disease before and after gluten exposure.