10 Facts About Cell proliferation

Cell proliferation is the process by which a cell grows and divides to produce two daughter cells.

Cell proliferation leads to an exponential increase in cell number and is therefore a rapid mechanism of tissue growth.

Cell proliferation requires both cell growth and cell division to occur at the same time, such that the average size of cells remains constant in the population.

Stem cells undergo cell proliferation to produce proliferating "transit amplifying" daughter cells that later differentiate to construct tissues during normal development and tissue growth, during tissue regeneration after damage, or in cancer.

Cell proliferation size depends on both cell growth and cell division, with a disproportionate increase in the rate of cell growth leading to production of larger cells and a disproportionate increase in the rate of cell division leading to production of many smaller cells.

Cell proliferation typically involves balanced cell growth and cell division rates that maintain a roughly constant cell size in the exponentially proliferating population of cells.

Cell proliferation occurs by combining cell growth with regular "G1-S-M-G2" cell cycles to produce many diploid cell progeny.

In single-celled organisms, cell proliferation is largely responsive to the availability of nutrients in the environment .

In multicellular organisms, the process of cell proliferation is tightly controlled by gene regulatory networks encoded in the genome and executed mainly by transcription factors including those regulated by signal transduction pathways elicited by growth factors during cell–cell communication in development.

Uncontrolled cell proliferation, leading to an increased proliferation rate, or a failure of cells to arrest their proliferation at the normal time, is a cause of cancer.