Chloroquine is a medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects.
| FactSnippet No. 1,131,796 |
12 Facts About Chloroquine
2.
Chloroquine is occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.
| FactSnippet No. 1,131,797 |
3.
Chloroquine has been used in the treatment and prevention of malaria from Plasmodium vivax, P ovale, and P malariae.
| FactSnippet No. 1,131,798 |
4.
Chloroquine has not been shown to have any harmful effects on the fetus when used in the recommended doses for malarial prophylaxis.
| FactSnippet No. 1,131,799 |
5.
Chloroquine has a number of drug–drug interactions that might be of clinical concern:.
| FactSnippet No. 1,131,800 |
6.
Chloroquine is a lysosomotropic agent, meaning it accumulates preferentially in the lysosomes of cells in the body.
| FactSnippet No. 1,131,801 |
7.
Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole.
| FactSnippet No. 1,131,802 |
8.
Chloroquine seems to act as a zinc ionophore that allows extracellular zinc to enter the cell and inhibit viral RNA-dependent RNA polymerase.
| FactSnippet No. 1,131,803 |
9.
Chloroquine comes in tablet form as the phosphate, sulfate, and hydrochloride salts.
| FactSnippet No. 1,131,804 |
10.
Chloroquine was proposed as a treatment for SARS, with in vitro tests inhibiting the SARS-CoV virus.
| FactSnippet No. 1,131,805 |
11.
Chloroquine was being considered in 2003, in pre-clinical models as a potential agent against chikungunya fever.
| FactSnippet No. 1,131,806 |
12.
Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19.
| FactSnippet No. 1,131,807 |