10 Facts About Cholera toxin

1.

Cholera toxin is AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae.

FactSnippet No. 1,428,273
2.

Cholera toxin was discovered in 1959 by Indian microbiologist Sambhu Nath De.

FactSnippet No. 1,428,274
3.

Complete Cholera toxin is a hexamer made up of a single copy of the A subunit, and five copies of the B subunit, denoted as AB5.

FactSnippet No. 1,428,275
4.

Once bound, the entire toxin complex is endocytosed by the cell and the cholera toxin A1 chain is released by the reduction of a disulfide bridge.

FactSnippet No. 1,428,276
5.

Pertussis Cholera toxin produced by Bordetella pertussis acts in a similar manner with the exception that it ADP-ribosylates the Gai subunit, rendering it unable to inhibit cAMP production.

FactSnippet No. 1,428,277

Related searches

Nath
6.

Gene encoding the cholera toxin is introduced into V cholerae by horizontal gene transfer.

FactSnippet No. 1,428,278
7.

Treatment of cultured rodent neural stem cells with cholera toxin induces changes in the localization of the transcription factor Hes3 and increases their numbers.

FactSnippet No. 1,428,279
8.

Since cholera toxin has been shown to preferentially bind to GM1 gangliosides, this characteristic can be utilized for membrane studies.

FactSnippet No. 1,428,280
9.

Cholera toxin has been shown to enter cells via endocytosis in multiple pathways.

FactSnippet No. 1,428,281
10.

One of the most important aspects of cholera toxin is the retrograde traffic mechanism that transports the toxin from the cell membrane back to the trans-Golgi network and the endoplasmic reticulum.

FactSnippet No. 1,428,282