12 Facts About Ciclosporin

Ciclosporin, spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication.

Ciclosporin is believed to work by decreasing the function of lymphocytes.

Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983.

Ciclosporin is indicated to treat and prevent graft-versus-host disease in bone marrow transplantation and to prevent rejection of kidney, heart, and liver transplants.

Ciclosporin has been used in people with acute severe ulcerative colitis and hives that do not respond to treatment with steroids.

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Ciclosporin, by preventing the dephosphorylation of NF-AT, leads to reduced effector T-cell function; it does not affect cytostatic activity.

Ciclosporin is a cyclic peptide of 11 amino acids; it contains a single D-amino acid, which is rarely encountered in nature.

Ciclosporin is highly metabolized in humans and animals after ingestion.

Ciclosporin is the INN and the British Approved Name, while cyclosporine is the United States Adopted Name and cyclosporin is a former BAN.

Ciclosporin was originally brought to market by Sandoz, under the brand name Sandimmune, which is available as soft gelatin capsules, an oral solution, and a formulation for intravenous administration.

Ciclosporin has been investigated as a possible neuroprotective agent in conditions such as traumatic brain injury, and has been shown in animal experiments to reduce brain damage associated with injury.

Ciclosporin has been used experimentally to treat cardiac hypertrophy .