1. Claudio Marchisio was the club's second vice-captain, behind Giorgio Chiellini, before his contract was terminated in 2018 and then signed with Russian club Zenit Saint Petersburg, where he stayed for one season, before retiring from professional football in 2019.
At the international level, Marchisio has represented Italy at the 2008 Summer Olympics, and at the 2010 and 2014 FIFA World Cups; he took part at UEFA Euro 2012, winning a runners-up medal, and at the 2013 FIFA Confederations Cup, where he won a third-place medal.
On 17 May 2011, Juventus announced that Claudio Marchisio had signed an improved, five-year contract with the club.
Claudio Marchisio was one of four Juventus players nominated for the 2012 UEFA Team of the Year and was voted into the Serie A Team of the Year at the Oscar del Calcio awards.
On 24 November, Claudio Marchisio was nominated for the 2015 UEFA Team of the Year.
On 1 July 2019, Zenit announced that Claudio Marchisio had left the club after his contract was terminated by mutual consent.
On 3 October 2019, Claudio Marchisio held a press conference at Juventus Stadium, where he announced his retirement from football.
Claudio Marchisio was initially called up in early May to the Italy under-21 squad for the 2007 European Championships but eventually withdrew due to injury.
Claudio Marchisio made his under-21 debut in June 2007, the group opening game of the 2009 European Championship qualifying, but his debut ended rather unfortunately as he was injured in a collision barely ten minutes into the match while attempting an effort on goal, although the shot would lead to Robert Acquafresca's opener seconds later.
On 12 August 2009, Claudio Marchisio made his senior debut, starting in the friendly against Switzerland that ended goalless and was praised by Marcello Lippi during the post-match interview.
Claudio Marchisio scored his first ever international goal in the Euro 2012 qualifier against Serbia on 7 October 2011, barely a minute after kick-off.
Under Prandelli, Claudio Marchisio became an established member of the Italy national team, and he was named in the final squad for the 2013 FIFA Confederations Cup, in which Italy finished third.
On 27 March 2015, Claudio Marchisio suffered an injury during a training session with the Italy national team, prior to the Euro 2016 qualifying match against Bulgaria.
In total, Claudio Marchisio made 55 appearances for Italy between 2009 and 2017, scoring five goals.
Claudio Marchisio has occupied a deeper playmaking role for his team, in particular after Pirlo's departure in 2015, in which he has been praised for his ability to spread the ball wide, or dictate play in midfield with his passing.
In 2021, Claudio Marchisio began writing as a columnist for the Turin edition of the Corriere della Sera.
On 3 May 2021, it was revealed that Claudio Marchisio's family had tested positive for COVID-19 in April amid its pandemic in Italy by his wife on Instagram.