Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, anxiety, and the movement disorder known as akathisia.
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17 Facts About Clonazepam
2.
Clonazepam was patented in 1960 and went on sale in 1975 in the United States from Roche.
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3.
Clonazepam is prescribed for short term management of epilepsy, anxiety, and panic disorder with or without agoraphobia.
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4.
Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam.
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5.
Clonazepam is mainly prescribed for the acute management of epilepsies.
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6.
Clonazepam has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many people, and the addition of phenytoin for lasting control was required in these patients.
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7.
Clonazepam is generally not recommended for use in elderly people for insomnia due to its high potency relative to other benzodiazepines.
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8.
Clonazepam has similar effectiveness to other benzodiazepines at often a lower dose.
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9.
Clonazepam has no effect on GABA levels and has no effect on gamma-aminobutyric acid transaminase.
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10.
Clonazepam is a 2'-chlorinated derivative of nitrazepam, which increases its potency due to electron-attracting effect of the halogen in the ortho-position.
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11.
Clonazepam is lipid-soluble, rapidly crosses the blood–brain barrier, and penetrates the placenta.
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12.
Clonazepam is metabolized extensively via nitroreduction by cytochrome P450 enzymes, including CYP3A4.
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13.
Clonazepam passes rapidly into the central nervous system, with levels in the brain corresponding with levels of unbound clonazepam in the blood serum.
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14.
Clonazepam passes through the blood–brain barrier easily, with blood and brain levels corresponding equally with each other.
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15.
Clonazepam was the second most frequently implicated benzodiazepine in ED visits.
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16.
Clonazepam was approved in the United States as a generic drug in 1997 and is manufactured and marketed by several companies.
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17.
Clonazepam is available as tablets and orally disintegrating tablets an oral solution, and as a solution for injection or intravenous infusion.
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