12 Facts About Diabetic nephropathy

Diabetic nephropathy, known as diabetic kidney disease, is the chronic loss of kidney function occurring in those with diabetes mellitus.

Diabetic nephropathy is the leading causes of chronic kidney disease and end-stage renal disease globally.

Pathophysiologic abnormalities in diabetic nephropathy usually begin with long-standing poorly controlled blood glucose levels.

Diabetic nephropathy is the most common cause of end-stage renal disease and is a serious complication that affects approximately one quarter of adults with diabetes in the United States.

Diabetic nephropathy is associated with an increased risk of death in general, particularly from cardiovascular disease.

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The clinical presentation of diabetic nephropathy is characterized by proteinuria, hypertension and progressive loss of kidney function.

Disease progression of diabetic nephropathy involves various clinical stages: hyperfiltration, microalbuminuria, macroalbuminuria, nephrotic proteinuria to progressive chronic kidney disease leading to end-stage renal disease .

Pathophysiology of diabetic nephropathy is thought to involve an interaction between hemodynamic and metabolic factors.

Patients with diabetic nephropathy might go on to develop end stage renal disease and require kidney transplantation or hemodialysis.

Success of diabetic nephropathy management depends greatly upon the ability of individuals to self-manage this condition, encompassing glycaemic control, and the adoption of healthy lifestyles.

Diabetic nephropathy affects approximately a third of patients with type 1 and type 2 diabetes mellitus.

Diabetic nephropathy is responsible for about a third of cases of ESRD worldwide, and an even larger fraction in the developed countries.