11 Facts About Diclofenac

Diclofenac, sold under the brand name Voltaren, among others, is a nonsteroidal anti-inflammatory drug used to treat pain and inflammatory diseases such as gout.

Diclofenac was patented in 1965 by Ciba-Geigy; it came into medical use in the United States in 1988.

Diclofenac is used to treat pain, inflammatory disorders, and dysmenorrhea.

Diclofenac is used commonly to treat mild to moderate postoperative or post-traumatic pain, in particular when inflammation is present, and is effective against menstrual pain and endometriosis.

Diclofenac is available in topical forms and has been found to be useful for osteoarthritis but not other types of long-term musculoskeletal pain.

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Diclofenac is often used to treat chronic pain associated with cancer, especially if inflammation is present.

Diclofenac consumption has been associated with significantly increased vascular and coronary risk in a study including coxib, diclofenac, ibuprofen and naproxen.

Diclofenac has a relatively high lipid solubility, making it one of the few NSAIDs that are able to enter the brain by crossing the blood-brain barrier.

Diclofenac was first synthesized by Alfred Sallmann and Rudolf Pfister and introduced as Voltaren by Ciba-Geigy in 1973, then in 2015 it was bought by GlaxoSmithKline.

Diclofenac formulations are available worldwide under many different trade names.

Diclofenac has been shown to harm freshwater fish species such as rainbow trout.