Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions.
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12 Facts About Digoxin
2.
Digoxin is one of the oldest medications used in the field of cardiology.
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3.
Digoxin has a half life of approximately 36 hours given at average doses in patients with normal renal function.
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4.
Digoxin is used intrafetally or amniotically during abortions in the late second trimester and third trimester of pregnancy.
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5.
Digoxin has important parasympathetic effects, particularly on the atrioventricular node.
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Sydney6.
Digoxin is usually given orally, but can be given by IV injection in urgent situations .
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7.
Digoxin elimination is mainly by renal excretion and involves P-glycoprotein, which leads to significant clinical interactions with P-glycoprotein inhibitor drugs.
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8.
Digoxin is used as a standard control substance to test for P-glycoprotein inhibition.
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9.
Digoxin appears to be a peripherally selective drug due to limited brain uptake caused by binding to P-glycoprotein.
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10.
In 1930, Digoxin was first isolated by Dr Sydney Smith from the foxglove plant, Digitalis lanata.
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11.
Digoxin was distinguishable from other glucosides by the olive-green colored solution produced from this reaction, completely free of red.
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12.
Digoxin has the ability to bind oestrogen receptors, and therefore it has been proposed that it might increase the risk of oestrogen-sensitive breast and uterine cancers.
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