Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria.
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10 Facts About Diphtheria toxin
2.
The Diphtheria toxin gene is encoded by a prophage called corynephage ß.
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3.
Diphtheria toxin is a single polypeptide chain of 535 amino acids consisting of two subunits linked by disulfide bridges, known as an A-B toxin.
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4.
Diphtheria toxin has been associated with the development of myocarditis.
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5.
Myocarditis secondary to diphtheria toxin is considered one of the biggest risks to unimmunized children.
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Alexandre Yersin6.
Diphtheria toxin was discovered in 1888 by Emile Roux and Alexandre Yersin.
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7.
In 1890, Emil Adolf von Behring developed an anti-Diphtheria toxin based on the blood of horses immunized with attenuated bacteria.
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8.
In 1951, Freeman found that the Diphtheria toxin gene was not encoded on the bacterial chromosome, but by a lysogenic phage infecting all toxigenic strains.
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9.
Resimmune is an immunoDiphtheria toxin that is in clinical trials in cutaneous T cell lymphoma patients.
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10.
Similar to other A-B toxins, diphtheria toxin is adept at transporting exogenous proteins across mammalian cell membranes, which are usually impermeable to large proteins.
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