18 Facts About DNA sequence

1.

DNA sequence sequencing has become a key technology in many areas of biology and other sciences such as medicine, forensics, and anthropology.

FactSnippet No. 1,425,816
2.

Since DNA sequence is an informative macromolecule in terms of transmission from one generation to another, DNA sequence sequencing is used in evolutionary biology to study how different organisms are related and how they evolved.

FactSnippet No. 1,425,817
3.

DNA sequence sequencing is being increasingly used to diagnose and treat rare diseases.

FactSnippet No. 1,425,818
4.

DNA sequence sequencing allows clinicians to identify genetic diseases, improve disease management, provide reproductive counseling, and more effective therapies.

FactSnippet No. 1,425,819
5.

DNA sequence testing has evolved tremendously in the last few decades to ultimately link a DNA sequence print to what is under investigation.

FactSnippet No. 1,425,820
6.

Testing DNA sequence is a technique which can detect specific genomes in a DNA sequence strand to produce a unique and individualized pattern.

FactSnippet No. 1,425,821
7.

Canonical structure of DNA sequence has four bases: thymine, adenine, cytosine, and guanine .

FactSnippet No. 1,425,822
8.

DNA sequence sequencing is the determination of the physical order of these bases in a molecule of DNA sequence.

FactSnippet No. 1,425,823
9.

Deoxyribonucleic acid was first discovered and isolated by Friedrich Miescher in 1869, but it remained under-studied for many decades because proteins, rather than DNA sequence, were thought to hold the genetic blueprint to life.

FactSnippet No. 1,425,824
10.

In 1953, James Watson and Francis Crick put forward their double-helix model of DNA sequence, based on crystallized X-ray structures being studied by Rosalind Franklin.

FactSnippet No. 1,425,825
11.

Advancements in sequencing were aided by the concurrent development of recombinant DNA sequence technology, allowing DNA sequence samples to be isolated from sources other than viruses.

FactSnippet No. 1,425,826
12.

Unlike pyrosequencing, the DNA sequence chains are extended one nucleotide at a time and image acquisition can be performed at a delayed moment, allowing for very large arrays of DNA sequence colonies to be captured by sequential images taken from a single camera.

FactSnippet No. 1,425,827
13.

DNA sequence nanoballs are simply formed by denaturing double stranded, adapter ligated libraries and ligating the forward strand only to a splint oligonucleotide to form a ssDNA sequence circle.

FactSnippet No. 1,425,828
14.

However, only short sequences of DNA are determined from each DNA nanoball which makes mapping the short reads to a reference genome difficult.

FactSnippet No. 1,425,829
15.

One end of DNA to be sequenced is attached to another bead, with both beads being placed in optical traps.

FactSnippet No. 1,425,830
16.

The DNA sequence is deduced based on the four readouts with lowered concentrations of each of the four nucleotide types, similarly to the Sanger method.

FactSnippet No. 1,425,831
17.

The production of raw DNA sequence data is only the beginning of its detailed bioinformatical analysis.

FactSnippet No. 1,425,832
18.

Human genetics have been included within the field of bioethics since the early 1970s and the growth in the use of DNA sequence sequencing has introduced a number of ethical issues.

FactSnippet No. 1,425,833