19 Facts About DNA vaccination

DNA vaccination vaccine is a type of vaccine that transfects a specific antigen-coding DNA vaccination sequence into the cells of an organism as a mechanism to induce an immune response.

DNA vaccination vaccines have theoretical advantages over conventional vaccines, including the "ability to induce a wider range of types of immune response".

DNA vaccination vaccines are members of the genetic vaccines, because they contain a genetic information that codes for the cellular production of an antigen.

DNA vaccination vaccines contain DNA vaccination that codes for specific antigens from a pathogen.

The DNA vaccination is injected into the body and taken up by cells, whose normal metabolic processes synthesize proteins based on the genetic code in the plasmid that they have taken up.

DNA vaccination immunization is being investigated as a means of developing antivenom sera.

DNA vaccination vaccines elicit the best immune response when high-expression vectors are used.

DNA vaccination vaccines have been introduced into animal tissues by multiple methods.

Gene gun delivery ballistically accelerates plasmid DNA vaccination that has been absorbed onto gold or tungsten microparticles into the target cells, using compressed helium as an accelerant.

One of the advantages of DNA vaccination vaccines is that they are able to induce cytotoxic T lymphocytes without the inherent risk associated with live vaccines.

DNA vaccination-raised antibody responses rise much more slowly than when natural infection or recombinant protein immunization occurs.

Additionally, the titres of specific antibodies raised by DNA vaccination are lower than those obtained after vaccination with a recombinant protein.

In other words, DNA vaccination immunization induces a qualitatively superior response.

Two theories dominate – that in vivo uptake of DNA vaccination occurs non-specifically, in a method similar to phago- or pinocytosis, or through specific receptors.

DNA vaccination generates an effective immune memory via the display of antigen-antibody complexes on follicular dendritic cells, which are potent B-cell stimulators.

Plasmid DNA vaccination itself appears to have an adjuvant effect on the immune system.

DNA vaccination-primed immune responses can be boosted by the administration of recombinant protein or recombinant poxviruses.

Priming with DNA vaccination focuses the immune response on the required immunogen, while boosting with the recombinant virus provides a larger amount of expressed antigen, leading to a large increase in specific CTL responses.

Such DNA vaccination-coated microparticles can be as effective at raising CTL as recombinant viruses, especially when mixed with alum.