20 Facts About Domperidone

Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting, certain gastrointestinal problems like gastroparesis, and to induce and promote breast milk production.

Domperidone was discovered in 1974 and was introduced for medical use in 1979.

Domperidone is available over-the-counter in many countries, for instance in Europe and elsewhere throughout the world.

Domperidone can be used to increase the transit of food through the stomach by increasing gastrointestinal peristalsis and hence to treat gastroparesis.

Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation.

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Domperidone can be used to relieve nausea and gastrointestinal symptoms in Parkinson's disease; it blocks peripheral D2 receptors but minimally crosses the blood–brain barrier in normal doses so has no effect on the extrapyramidal symptoms of the disease.

Domperidone is available for use by oral administration in the form of tablets, orally disintegrating tablets, and suspension, and by rectal administration in the form of suppositories.

Domperidone has been studied for use by intramuscular injection and an intravenous formulation was previously available, but the medication is only available in forms for oral and rectal administration.

Domperidone use is associated with an increased risk of sudden cardiac death most likely through its prolonging effect of the cardiac QT interval and ventricular arrhythmias.

Domperidone is associated with a small increased risk of serious cardiac side effects.

Domperidone is contraindicated in those with underlying cardiac conditions and other risk factors.

Domperidone is a peripherally selective dopamine D2 and D3 receptor antagonist.

Domperidone is extensively metabolized in the liver and intestines with oral administration.

Domperidone is a benzimidazole derivative and is structurally related to butyrophenone neuroleptics like haloperidol.

Domperidone was synthesized at Janssen Pharmaceutica in 1974 following the research on antipsychotic drugs.

Domperidone was patented in the United States in 1978, with the patent filed in 1976.

Domperidone was introduced in the forms of orally disintegrating tablets in 1999.

Domperidone is the generic name of the drug and its INN, USAN, BAN, and JAN.

Domperidone is not generally approved for use in the United States.

Domperidone has been studied as a potential hormonal contraceptive to prevent pregnancy in women.