Doxycycline is a broad-spectrum tetracycline class antibiotic used in the treatment of infections caused by bacteria and certain parasites.
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10 Facts About Doxycycline
2.
Doxycycline was patented in 1957 and came into commercial use in 1967.
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3.
Doxycycline is active against the erythrocytic stages of Plasmodium falciparum but not against the gametocytes of P falciparum.
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4.
Doxycycline kills the symbiotic Wolbachia bacteria in the reproductive tracts of parasitic filarial nematodes, making the nematodes sterile, and thus reducing transmission of diseases such as onchocerciasis and elephantiasis.
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5.
Doxycycline is used for sclerotherapy in slow-flow vascular malformations, namely venous and lymphatic malformations, as well as post-operative lymphoceles.
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7.
Doxycycline is less likely than other antibiotic drugs to cause Clostridium difficile colitis.
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8.
Doxycycline use has been associated with increased risk of inflammatory bowel disease.
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9.
Doxycycline is highly lipophilic so can easily enter cells, meaning the drug is easily absorbed after oral administration and has a large volume of distribution.
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10.
Doxycycline is used in "tet-on" and "tet-off" tetracycline-controlled transcriptional activation to regulate transgene expression in organisms and cell cultures.
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