10 Facts About Flunitrazepam

Flunitrazepam, known as Rohypnol among other names, is a benzodiazepine used to treat severe insomnia and assist with anesthesia.

Flunitrazepam seems to have a particularly high risk of road traffic accidents compared to other hypnotic drugs.

Flunitrazepam is a drug that is frequently involved in drug intoxication, including overdose.

Flunitrazepam overdose responds to the GABAA receptor antagonist flumazenil, which thus can be used as a treatment.

Flunitrazepam can be measured in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest, or assist in a medicolegal death investigation.

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Flunitrazepam is lipophilic and is metabolised by the liver via oxidative pathways.

Flunitrazepam was discovered at Roche as part of the benzodiazepine work led by Leo Sternbach; the patent application was filed in 1960 and it was first marketed in 1972.

Flunitrazepam is known to induce anterograde amnesia in sufficient doses; individuals are unable to remember certain events that they experienced while under the influence of the drug, which complicates investigations.

Flunitrazepam is a Schedule III drug under the international Convention on Psychotropic Substances of 1971.

Flunitrazepam is marketed under many brand names in the countries where it is legal.