Folinic acid, known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine.
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11 Facts About Folinic acid
2.
Folinic acid is a form of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.
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3.
Folinic acid can be taken as a pill or injected into a vein or muscle .
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4.
Additionally, folinic acid is sometimes used to reduce the side effects of methotrexate in rheumatoid arthritis patients.
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5.
Folinic acid is used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer.
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AIDS6.
Folinic acid is sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors such as trimethoprim and pyrimethamine.
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7.
Folinic acid is used in the treatment of cerebral folate deficiency, a syndrome in which the use of folic acid cannot normalize cerebrospinal fluid levels of 5-MTHF.
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8.
Folinic acid has been shown to decrease the efficacy of sulfamethoxazole-trimethoprim in the treatment of Pneumocystis jirovecii, a common cause of pneumonia in AIDS patients.
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9.
In 1980s folinic acid was found to reactivate the dihydrofolate reductase itself even when methotrexate exists.
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10.
Folinic acid was discovered as a needed growth factor for the bacterium Leuconostoc citrovorum in 1948, by Sauberlich and Baumann.
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11.
However, folinic acid is a vitamer for folic acid and has the full vitamin activity of this vitamin.
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