George Gow Brownlee is a British pathologist and Fellow of Lincoln College, Oxford.
11 Facts About George Brownlee
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George Brownlee was Professor of Chemical Pathology at Sir William Dunn School of Pathology, from 1978 to 2008.
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George Brownlee cloned and expressed human clotting factor IX, providing a recombinant source of this protein for Haemophilia B patients who had previously relied on the hazardous blood-derived product.
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George Brownlee authored a biography of Fred Sanger published in 2014.
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George Brownlee was awarded The Colworth Medal by the Biochemical Society in 1976 and elected a Fellow of the Royal Society in 1987.
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George Brownlee contributed to the development of methods using 32P-labelling and two-dimensional fractionation techniques, which greatly accelerated the early RNA sequencing.
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George Brownlee used these methods to determine the sequence of the 5S ribosomal RNA, at that time the largest nucleic acid to be sequenced.
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George Brownlee used fingerprint analysis of messenger RNA to demonstrate that immunoglobulin V- and C-regions were not discontinuous at the messenger RNA level, and early analysis of messenger RNA to identify a precursor for light chain synthesis.
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George Brownlee studied the DNA sequence of the ovalbumin gene and its insertion sequences.
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George Brownlee determined the nucleotide sequence of the multiple gene coding for the 5S RNA in Xenopus laevis and showed that the coding regions alternated with a repetitious region and a "pseudogene" that had a sequence homologous with part of the 5S region.
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George Brownlee was elected a Fellow of the Academy of Medical Sciences in 1998 and an EMBO Member in 1979.