Higher native HDL cholesterol levels are correlated with lowered risk of cardiovascular disease in healthy people.
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10 Facts About HDL cholesterol
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2.
Liver synthesizes these lipoproteins as complexes of apolipoproteins and phospholipid, which resemble HDL cholesterol-free flattened spherical lipoprotein particles, whose NMR structure was recently published; the complexes are capable of picking up HDL cholesterol, carried internally, from cells by interaction with the ATP-binding cassette transporter A1.
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3.
The triglycerides are not stable in HDL, but are degraded by hepatic lipase so that, finally, small HDL particles are left, which restart the uptake of cholesterol from cells.
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4.
Several steps in the metabolism of HDL can participate in the transport of cholesterol from lipid-laden macrophages of atherosclerotic arteries, termed foam cells, to the liver for secretion into the bile.
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5.
HDL cholesterol carries many lipid and protein species, several of which have very low concentrations but are biologically very active.
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6.
Recent studies confirm the fact that HDL cholesterol has a buffering role in balancing the effects of the hypercoagulable state in type 2 diabetics and decreases the high risk of cardiovascular complications in these patients.
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7.
Epidemiological studies have shown that high concentrations of HDL cholesterol have protective value against cardiovascular diseases such as ischemic stroke and myocardial infarction.
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8.
Clinical laboratories formerly measured HDL cholesterol by separating other lipoprotein fractions using either ultracentrifugation or chemical precipitation with divalent ions such as Mg, then coupling the products of a cholesterol oxidase reaction to an indicator reaction.
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9.
High LDL with low HDL cholesterol level is an additional risk factor for cardiovascular disease.
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10.
PPAR modulator GW501516 has shown a positive effect on HDL cholesterol-C and an antiatherogenic where LDL is an issue.
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