12 Facts About Hodgkin lymphoma

1.

Hodgkin lymphoma is a type of lymphoma, in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells are present in the patient's lymph nodes.

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2.

About half of cases of Hodgkin lymphoma are due to Epstein–Barr virus and these are generally the classic form.

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3.

Hodgkin lymphoma must be distinguished from non-cancerous causes of lymph node swelling and from other types of cancer.

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4.

Classic Hodgkin lymphoma can be subclassified into four pathologic subtypes based upon Reed–Sternberg cell morphology and the composition of the reactive cell infiltrate seen in the lymph node biopsy specimen .

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5.

Hodgkin lymphoma cells produce interleukin-21, which was once thought to be exclusive to T-cells.

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Marcello Malpighi
6.

The use of rituximab in Hodgkin lymphoma, including the lymphocyte predominant subtype has been recently reviewed.

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7.

High cure rates and long survival of many people with Hodgkin lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute leukemias, lymphomas, and solid tumors within the radiation therapy field.

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8.

Treatment of Hodgkin lymphoma's disease has been improving over the past few decades.

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9.

Hodgkin lymphoma was first described in an 1832 report by Thomas Hodgkin, although Hodgkin noted that perhaps an earlier reference to the condition was provided by Marcello Malpighi in 1666.

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10.

Hodgkin lymphoma's paper went largely unnoticed even though Bright highlighted it in an 1838 publication.

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11.

Indeed, Hodgkin lymphoma himself did not view his contribution as particularly significant.

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12.

Hodgkin lymphoma was one of the first cancers to be treated successfully with radiation therapy and, later, it was one of the first to be treated by combination chemotherapy.

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