12 Facts About Hodgkin lymphoma

Hodgkin lymphoma is a type of lymphoma, in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells are present in the patient's lymph nodes.

About half of cases of Hodgkin lymphoma are due to Epstein–Barr virus and these are generally the classic form.

Hodgkin lymphoma must be distinguished from non-cancerous causes of lymph node swelling and from other types of cancer.

Classic Hodgkin lymphoma can be subclassified into four pathologic subtypes based upon Reed–Sternberg cell morphology and the composition of the reactive cell infiltrate seen in the lymph node biopsy specimen .

Hodgkin lymphoma cells produce interleukin-21, which was once thought to be exclusive to T-cells.

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The use of rituximab in Hodgkin lymphoma, including the lymphocyte predominant subtype has been recently reviewed.

High cure rates and long survival of many people with Hodgkin lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute leukemias, lymphomas, and solid tumors within the radiation therapy field.

Treatment of Hodgkin lymphoma's disease has been improving over the past few decades.

Hodgkin lymphoma was first described in an 1832 report by Thomas Hodgkin, although Hodgkin noted that perhaps an earlier reference to the condition was provided by Marcello Malpighi in 1666.

Hodgkin lymphoma's paper went largely unnoticed even though Bright highlighted it in an 1838 publication.

Indeed, Hodgkin lymphoma himself did not view his contribution as particularly significant.

Hodgkin lymphoma was one of the first cancers to be treated successfully with radiation therapy and, later, it was one of the first to be treated by combination chemotherapy.