13 Facts About Intrinsic apoptosis

In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, Intrinsic apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle.

Unlike necrosis, Intrinsic apoptosis produces cell fragments called apoptotic bodies that phagocytes are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them.

Intrinsic apoptosis shared the prize with Boston biologist H Robert Horvitz.

Many years, neither "Intrinsic apoptosis" nor "programmed cell death" was a highly cited term.

Initiation of Intrinsic apoptosis is tightly regulated by activation mechanisms, because once Intrinsic apoptosis has begun, it inevitably leads to the death of the cell.

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The X-linked inhibitor of Intrinsic apoptosis protein is overexpressed in cells of the H460 cell line.

For instance, treatments aim to restore Intrinsic apoptosis to treat diseases with deficient cell death and to increase the apoptotic threshold to treat diseases involved with excessive cell death.

At the molecular level, hyperactive Intrinsic apoptosis can be caused by defects in signaling pathways that regulate the Bcl-2 family proteins.

Viral induction of Intrinsic apoptosis occurs when one or several cells of a living organism are infected with a virus, leading to cell death.

However, Intrinsic apoptosis induced by CDV in HeLa cells does not involve the initiator protein caspase-8.

The study of Intrinsic apoptosis brought on by Bunyaviridae was initiated in 1996, when it was observed that Intrinsic apoptosis was induced by the La Crosse virus into the kidney cells of baby hamsters and into the brains of baby mice.

In order for Intrinsic apoptosis to occur within OROV, viral uncoating, viral internalization, along with the replication of cells is necessary.

However, studies have demonstrated that the OROV infection causes Intrinsic apoptosis to be activated through intracellular stimuli and involves the mitochondria.