12 Facts About Isoniazid

Isoniazid, known as isonicotinic acid hydrazide, is an antibiotic used for the treatment of tuberculosis.

Isoniazid is often used to treat latent and active tuberculosis infections.

Isoniazid has been approved as prophylactic therapy for the following populations:.

Isoniazid can be used alone or in combination with Rifampin for treatment of latent tuberculosis, or as part of a four-drug regimen for treatment of active tuberculosis.

Isoniazid was widely used in the treatment of Mycobacterium avium complex as part of a regimen including rifampicin and ethambutol.

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Isoniazid has a boxed warning for severe and sometimes fatal hepatitis, which is age-dependent at a rate of 0.

Isoniazid is associated with pyridoxine deficiency because of its similar structure.

Isoniazid was found to significantly elevate the in vivo concentration of GABA and homocarnosine in a single subject via magnetic resonance spectroscopy.

Isoniazid is thought to induce a liver enzyme which causes a larger amount of acetaminophen to be metabolized to a toxic form.

Isoniazid is a prodrug that inhibits the formation of the mycobacterial cell wall.

Isoniazid must be activated by KatG, a bacterial catalase-peroxidase enzyme in Mycobacterium tuberculosis.

Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.