12 Facts About Jonathon Pines

Jonathon Noe Joseph Pines was born on 11 October 1961 and is head of the Cancer Biology Division at the Institute of Cancer Research in London.

Jonathon Pines was formerly a senior group leader at the Gurdon Institute at the University of Cambridge.

Jonathon Pines pioneered the use of fluorescent tags to analyse the dynamic behaviour and stability of these regulators in living cells.

Jonathon Pines discoveries have revealed that mitotic regulators are targeted to specific substructures at specific times, and that mitosis is exquisitely coordinated by the destruction of key regulators at different times in cell division.

Jonathon Pines work has provided insights into how chromosome behaviour in mitosis controls both the time and the rate at which essential mitotic regulators are destroyed, and these discoveries have wider implications for how cancers develop.

Since 2020, Jonathon Pines has been Editor-in-Chief of the Royal Society journal Open Biology.

Jonathon Pines was elected a member of the European Molecular Biology Organisation in 2001 and a Fellow of the Academy of Medical Sciences in 2005.

Jonathon Pines has made key discoveries in the cell cycle field, many of which have opened up new avenues of research.

Jonathon Pines cloned the original 'cyclin' as a PhD student with Tim Hunt and demonstrated that it had mitosis-promoting activity.

Jonathon Pines has developed a novel live-cell assay for proteolysis and uncovered new mechanisms by which cells control mitosis.

Jonathon Pines's analyses have shown how ubiquitin-mediated proteolysis coordinates chromosome congression with cytokinesis and mitotic exit by degrading specific proteins at specific times.

Jonathon Pines was elected a Fellow of the Royal Society in 2016.