10 Facts About Lolitrem B

Lolitrem B is one of many toxins produced by a fungus called Epichloe festucae var.

Lolitrem B is one of these toxins, but it is harmful to mammals.

The effect of the lolitrem B comes on slowly and fades out slowly, as it is stored in fat after the ryegrass is eaten.

Lolitrem B toxin derives the first part of its name from the host of the fungus, the middle part due to the tremors the toxin is known to cause, and the last part of its name as part of a way to distinguish between different Lolitrems, based on their difference in chemical structure .

Lolitrem B is found in perennial ryegrass that has been infected with the fungus E f lolii .

Lolitrem B is rapidly eliminated from serum and has a half-life of 14 minutes.

Lolitrem B is not very soluble, and is generally stored in fat after ingestion and slowly released; this is likely why its effects come on slowly and linger after ingestion has stopped.

When lolitrem B is added, the potassium current quickly gets abolished and this inhibition cannot be reversed by washout .

Lolitrem B is a more potent neurotoxin in vitro compared to paxilline.

Lolitrem B has the highest affinity for BK channels when there is a high probability of an open conformation thus when the calcium binds to the high affinity sites.