16 Facts About Messenger RNA

MMessenger RNA is created during the process of transcription, where an enzyme converts the gene into primary transcript mMessenger RNA .

Mature mMessenger RNA is then read by the ribosome, and, utilising amino acids carried by transfer Messenger RNA, the ribosome creates the protein.

Concept of mMessenger RNA was developed by Sydney Brenner and Francis Crick in 1960.

In 1961, mMessenger RNA was isolated and described independently by James Watson's research team and a team of Jacob, Monod and Matthew Meselson.

Brief existence of an mMessenger RNA molecule begins with transcription, and ultimately ends in degradation.

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Non-eukaryotic mMessenger RNA is, in essence, mature upon transcription and requires no processing, except in rare cases.

Eukaryotic pre-mMessenger RNA requires several processing steps before its transport to the cytoplasm and its translation by the ribosome.

Shortly after the start of transcription, the 5' end of the mMessenger RNA being synthesized is bound by a cap-synthesizing complex associated with Messenger RNA polymerase.

In some instances, an mMessenger RNA will be edited, changing the nucleotide composition of that mMessenger RNA.

In eukaryotic organisms most messenger RNA molecules are polyadenylated at the 3' end, but recent studies have shown that short stretches of uridine are common.

One site of mMessenger RNA translation is at polyribosomes selectively localized beneath synapses.

An mMessenger RNA molecule is said to be monocistronic when it contains the genetic information to translate only a single protein chain .

The limited lifetime of mMessenger RNA enables a cell to alter protein synthesis rapidly in response to its changing needs.

Rapid mMessenger RNA degradation via AU-rich elements is a critical mechanism for preventing the overproduction of potent cytokines such as tumor necrosis factor and granulocyte-macrophage colony stimulating factor .

For instance, in one of the earliest reports, Jacques Monod and his team showed that RNA synthesis was necessary for protein synthesis, specifically during the production of the enzyme ß-galactosidase in the bacterium, E coli.

Idea of mMessenger RNA was first conceived by Sydney Brenner and Francis Crick on 15 April 1960 at King's College, Cambridge, while Francois Jacob was telling them about a recent experiment conducted by Arthur Pardee, himself, and Monod.