Mirtazapine, sold under the brand name Remeron amongst others, is an atypical antidepressant, and as such is used primarily to treat depression.
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16 Facts About Mirtazapine
2.
The effectiveness of Mirtazapine is comparable to other commonly prescribed antidepressants.
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4.
Mirtazapine is primarily used for major depressive disorder and other mood disorders.
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5.
Mirtazapine has been associated with an increased risk of death compared to other antidepressants in several studies.
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6.
Mirtazapine is considered to be relatively safe in the event of an overdose, although it is considered slightly more toxic in overdose than most of the SSRIs.
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7.
Mirtazapine is a potent 5-HT2A receptor antagonist, and cyproheptadine, a medication that shares this property, mediates recovery from serotonin syndrome and is an antidote against it.
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8.
Mirtazapine is sometimes described as a noradrenergic and specific serotonergic antidepressant, although the actual evidence in support of this label has been regarded as poor.
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9.
Mirtazapine has been shown to lower drug seeking behaviour in various human and animal studies.
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10.
Mirtazapine significantly improves pre-existing symptoms of nausea, vomiting, diarrhea, and irritable bowel syndrome in affected individuals.
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11.
Mirtazapine is a very strong H1 receptor inverse agonist and, as a result, it can cause powerful sedative and hypnotic effects.
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12.
Mirtazapine is a tetracyclic piperazinoazepine; mianserin was developed by the same team of organic chemists and mirtazapine differs from it via addition of a nitrogen atom in one of the rings.
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13.
Mirtazapine was first synthesized at Organon and published in 1989, was first approved for use in major depressive disorder in the Netherlands in 1994, and was introduced in the United States in 1996 under the brand name Remeron.
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14.
Mirtazapine is the English and French generic name of the drug and its INN, USAN, USP, BAN, DCF, and JAN.
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15.
Mirtazapine is sometimes prescribed as an appetite stimulant for cats or dogs experiencing loss of appetite due to medical conditions such as chronic kidney disease.
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16.
Mirtazapine is indicated for bodyweight gain in cats experiencing poor appetite and weight loss resulting from chronic medical conditions.
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