Mladen Vranic was born in 1930 to Vladimir Vranic and Ana Vranic in Zagreb, Croatia.
23 Facts About Mladen Vranic
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Mladen Vranic's father was a professor at the Faculty of Economics, Engineering, and Sciences, and Dean at the School of Economics and Engineering at the University of Zagreb.
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Mladen Vranic was invited to be the last post-doctoral fellow of Charles Best, a co-discoverer of insulin.
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Mladen Vranic was promoted to assistant professor in 1965, associate professor in 1968 and full professor in 1972 at the University of Toronto Department of Physiology.
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Mladen Vranic was chair of the Department of Physiology from 1991 to 1995.
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Mladen Vranic was an adjunct professor at the Karolinska Institute, Stockholm and at the University of Zagreb, Croatia.
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Mladen Vranic is a member of the division of endocrinology and metabolism at the department of medicine and a fellow at the Senior Scholar's College at the University of Toronto.
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Mladen Vranic's first wife, Magda Vranic, was an assistant professor in rehabilitation medicine at the University of Toronto.
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Mladen Vranic died of breast cancer at the age of 50.
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Mladen Vranic died on June 18,2019, in Toronto, Canada, of congestive heart failure.
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Mladen Vranic has 214 peer-reviewed publications and is recognized for his research contributions in the following areas:.
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Mladen Vranic quantified hormonal and metabolic interactions involved in the physiology and pathogenesis of diabetes by developing tracer methods to separate the effects of diabetes on both.
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Mladen Vranic collaborated in the first clinical tracer studies on insulin resistance, hypertriglyceridemia, and the Cori cycle.
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Mladen Vranic discovered extrapancreatic glucagon in dogs, which changed the prevailing dogma and permitted precise exploration of the roles of insulin and glucagon in physiology and diabetes, and provided conclusive evidence about the role of glucagon in diabetes.
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Mladen Vranic was the first to quantify the physiological secretion of insulin.
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Mladen Vranic was the first to establish the critical role of glucagon-insulin interaction and the control of glucose metabolism during moderate exercise and of catecholamines during strenuous exercise.
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Mladen Vranic quantified the deficiencies in the release and effects of these hormones in diabetes.
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Mladen Vranic revealed how acute and chronic hyperglycemia affects the expression of GLUT2 gene and protein in diabetes.
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Mladen Vranic pioneered new concepts of the role of exercise in diabetes, leading to precise methods of controlling insulin, allowing type 1 diabetics to participate in the Olympics and clinicians to recommend exercise and healthy eating habits to prevent type 2 diabetes.
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Mladen Vranic outlined molecular and physiological mechanisms whereby exercise training and adaptation to repetitive neurogenic stress can prevent diabetes in Zucker Diabetic Fatty rats.
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Mladen Vranic showed that because the muscle and the liver are protected against changes in glucose levels, these organs do not have diabetic complications.
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Mladen Vranic described the molecular mechanisms responsible for increased HPA axis in diabetes and for the diminished responses of HPA axis, catecholamines and glucagon to hypoglycemia.
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Mladen Vranic proposed a new approach to decrease the threat of hypoglycemia by blocking the effect of somatostatin.