12 Facts About Muscimol


Muscimol is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom.

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Muscimol is a potent and selective orthosteric agonist for the GABAA receptors and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity.

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Muscimol went under clinical trial phase I for epilepsy, but the trial was discontinued.

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Muscimol is one of the psychoactive compounds responsible for the effects of Amanita muscaria intoxication.

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Muscimol is produced in the mushrooms Amanita muscaria and Amanita pantherina, along with muscarine (which is present in trace amounts and it is not active), muscazone, and ibotenic acid.

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Muscimol is a potent GABAA agonist, activating the receptor for the brain's principal inhibitory neurotransmitter, GABA.

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Muscimol was first isolated from Amanita pantherina by Onda in 1964, and thought to be an amino acid or peptide.

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Muscimol is a semi-rigid isoxazole containing both alcohol and aminomethyl substituents.

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Muscimol is commonly portrayed as a tautomer, where it adopts an amide-like configuration.

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Muscimol can be extracted from the flesh of the Amanita muscaria by treatment with boiling water, followed by rapid cooling, and further treatment with a basic resin.

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Muscimol was synthesized in 1965 by Gagneux, who utilized a bromo-isoxazole starting material in a two step reaction.

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Muscimol is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard.

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