Muscimol is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom.
| FactSnippet No. 624,465 |
12 Facts About Muscimol
2.
Muscimol is a potent and selective orthosteric agonist for the GABAA receptors and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity.
| FactSnippet No. 624,466 |
3.
Muscimol went under clinical trial phase I for epilepsy, but the trial was discontinued.
| FactSnippet No. 624,467 |
4.
Muscimol is one of the psychoactive compounds responsible for the effects of Amanita muscaria intoxication.
| FactSnippet No. 624,468 |
5.
Muscimol is produced in the mushrooms Amanita muscaria and Amanita pantherina, along with muscarine (which is present in trace amounts and it is not active), muscazone, and ibotenic acid.
| FactSnippet No. 624,469 |
6.
Muscimol is a potent GABAA agonist, activating the receptor for the brain's principal inhibitory neurotransmitter, GABA.
| FactSnippet No. 624,470 |
7.
Muscimol was first isolated from Amanita pantherina by Onda in 1964, and thought to be an amino acid or peptide.
| FactSnippet No. 624,471 |
8.
Muscimol is a semi-rigid isoxazole containing both alcohol and aminomethyl substituents.
| FactSnippet No. 624,472 |
9.
Muscimol is commonly portrayed as a tautomer, where it adopts an amide-like configuration.
| FactSnippet No. 624,473 |
10.
Muscimol can be extracted from the flesh of the Amanita muscaria by treatment with boiling water, followed by rapid cooling, and further treatment with a basic resin.
| FactSnippet No. 624,474 |
11.
Muscimol was synthesized in 1965 by Gagneux, who utilized a bromo-isoxazole starting material in a two step reaction.
| FactSnippet No. 624,475 |
12.
Muscimol is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard.
| FactSnippet No. 624,476 |