10 Facts About P53

The TP53 gene is the most frequently mutated gene in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation.

TP53 orthologs have been identified in most mammals for which complete genome data are available.

P53 plays a role in regulation or progression through the cell cycle, apoptosis, and genomic stability by means of several mechanisms:.

P53 by regulating Leukemia Inhibitory Factor has been shown to facilitate implantation in the mouse and possibly humans reproduction.

P53 becomes activated in response to myriad stressors, including but not limited to DNA damage, oxidative stress, osmotic shock, ribonucleotide depletion, and deregulated oncogene expression.

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P53 protein is continually produced and degraded in cells of healthy people, resulting in damped oscillation .

Large spectrum of cancer phenotypes due to mutations in the TP53 gene is supported by the fact that different isoforms of p53 proteins have different cellular mechanisms for prevention against cancer.

Mutations in TP53 can give rise to different isoforms, preventing their overall functionality in different cellular mechanisms and thereby extending the cancer phenotype from mild to severe.

The human TP53 gene was cloned in 1984 and the full length clone in 1985.

Warren Maltzman, of the Waksman Institute of Rutgers University first demonstrated that TP53 was responsive to DNA damage in the form of ultraviolet radiation.