10 Facts About Pentobarbital

1.

Pentobarbital is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies.

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2.

Pentobarbital was widely abused and sometimes known as "yellow jackets" due to the yellow capsule of the Nembutal brand.

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3.

Pentobarbital was widely abused, known on the street as "yellow jackets".

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4.

Pentobarbital can reduce intracranial pressure in Reye's syndrome, treat traumatic brain injury and induce coma in cerebral ischemia patients.

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5.

Pentobarbital-induced coma has been advocated in patients with acute liver failure refractory to mannitol.

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6.

Pentobarbital has been used or considered as a substitute for other drugs previously used for capital punishment in the United States when those drugs are unavailable.

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7.

Pentobarbital undergoes first-pass metabolism in the liver and possibly the intestines.

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8.

Pentobarbital is synthesized by methods analogous to that of amobarbital, the only difference being that the alkylation of a-ethylmalonic ester is carried out with 2-bromopentane in place of 1-bromo-3-methylbutane to give pentobarbital.

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9.

Pentobarbital is the INN, AAN, BAN, and USAN while pentobarbitone is a former AAN and BAN.

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10.

Pentobarbital can occur as a free acid, but is usually formulated as the sodium salt, pentobarbital sodium.

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