10 Facts About Receptor ligand

In biochemistry and pharmacology, a Receptor ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

In protein-Receptor ligand binding, the Receptor ligand is usually a molecule which produces a signal by binding to a site on a target protein.

In DNA-Receptor ligand binding studies, the Receptor ligand can be a small molecule, ion, or protein which binds to the DNA double helix.

The relationship between Receptor ligand and binding partner is a function of charge, hydrophobicity, and molecular structure.

In general, the interpretation of Receptor ligand is contextual with regards to what sort of binding has been observed.

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In general, high-affinity ligand binding results from greater attractive forces between the ligand and its receptor while low-affinity ligand binding involves less attractive force.

In general, high-affinity binding results in a higher occupancy of the receptor by its ligand than is the case for low-affinity binding; the residence time does not correlate.

Low-affinity binding implies that a relatively high concentration of a Receptor ligand is required before the binding site is maximally occupied and the maximum physiological response to the Receptor ligand is achieved.

Ligand efficacy refers to the ability of the ligand to produce a biological response upon binding to the target receptor and the quantitative magnitude of this response.

Main methods to study protein–Receptor ligand interactions are principal hydrodynamic and calorimetric techniques, and principal spectroscopic and structural methods such as.