13 Facts About RNA splicing

1.

RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA transcript is transformed into a mature messenger RNA .

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2.

For nuclear-encoded genes, RNA splicing occurs in the nucleus either during or immediately after transcription.

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3.

For those eukaryotic genes that contain introns, splicing is usually needed to create an mRNA molecule that can be translated into protein.

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4.

For many eukaryotic introns, RNA splicing occurs in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins .

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5.

Several methods of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur.

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6.

In most cases, splicing removes introns as single units from precursor mRNA transcripts.

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7.

However, in some cases, especially in mRNAs with very long introns, splicing happens in steps, with part of an intron removed and then the remaining intron is spliced out in a following step.

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8.

TRNA splicing is another rare form of splicing that usually occurs in tRNA.

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9.

The RNA splicing reaction involves a different biochemistry than the spliceosomal and self-RNA splicing pathways.

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10.

Yeast tRNA splicing ligase adds an adenosine monophosphate group to the 5' end of the 3'-half and joins the two halves together.

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11.

Process of RNA splicing is linked with HIV integration, as HIV-1 targets highly spliced genes.

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12.

Allelic differences in mRNA splicing are likely to be a common and important source of phenotypic diversity at the molecular level, in addition to their contribution to genetic disease susceptibility.

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13.

Protein RNA splicing has been observed in a wide range of organisms, including bacteria, archaea, plants, yeast and humans.

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