Stephen Joseph Elledge was born on August 7,1956 and is an American geneticist.
19 Facts About Stephen Elledge
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Stephen Elledge is the current Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women's Hospital.
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Stephen Elledge's research is focused on the genetic and molecular mechanisms of eukaryotic response to DNA damage and is known as the discoverer of the DNA damage response.
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Stephen Elledge grew in up, graduating from Paris High School in 1974.
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Stephen Elledge has been interested in chemistry since childhood, thanks to a chemistry set his grandmother gave him.
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Stephen Elledge entered the University of Illinois Urbana-Champaign, majoring in chemistry and hoping to become an organic chemist.
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Stephen Elledge took biochemistry courses after returning to Illinois, which prompted him to study PhD in biology at the Massachusetts Institute of Technology after obtaining his BSc in 1978.
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In 2003, Stephen Elledge joined the Department of Genetics of Harvard Medical School.
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Currently, Stephen Elledge is the Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women's Hospital.
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Stephen Elledge sits on the Board of Advisory Scientists of the Whitehead Institute and the advisory board of Molecular Cell.
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Stephen Elledge has been an investigator at the Howard Hughes Medical Institute since 1993.
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Stephen Elledge began studying DNA repair during his years at Stanford University as a postdoctoral fellow.
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Stephen Elledge accidentally discovered the RNR2 gene and protein in yeast, which belongs to the family of ribonucleotide reductase, and found that its expression increases when DNA is damaged.
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Stephen Elledge showed that the Rb protein physically associates with PP1a from mitosis until mid-G1 phase in yeasts.
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Stephen Elledge's group discovered the F-box protein structural motif, and found that it recognizes specific protein sequences and tags the proteins with ubiquitin for degradation.
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Stephen Elledge correctly predicted the central role of F-Box in protein degradation due to the large number of proteins having this motif.
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In 2015, Stephen Elledge's group developed VirScan, a platform that detects viral infection in patients from a small amount of blood.
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In recent years, Stephen Elledge has continued to expand his research area.
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Stephen Elledge was married to Mitzi Kuroda, herself a professor at the Department of Genetics at Harvard Medical School.