Substance P is an undecapeptide member of the tachykinin neuropeptide family.
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10 Facts About Substance P
2.
Substance P is released from the terminals of specific sensory nerves.
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3.
Original discovery of Substance P was in 1931 by Ulf von Euler and John H Gaddum as a tissue extract that caused intestinal contraction in vitro.
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4.
Substance P is a neuropeptide – but only nominally so, as it is ubiquitous.
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5.
Substance P is involved in the axon reflex-mediated vasodilation to local heating and wheal and flare reaction.
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Euler6.
Preclinical data support the notion that Substance P is an important element in pain perception.
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7.
The sensory function of substance P is thought to be related to the transmission of pain information into the central nervous system.
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8.
Substance P has been associated with the regulation of mood disorders, anxiety, stress, reinforcement, neurogenesis, respiratory rhythm, neurotoxicity, pain, and nociception.
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9.
Substance P has been known to stimulate cell growth in normal and cancer cell line cultures, and it was shown that substance P could promote wound healing of non-healing ulcers in humans.
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10.
High levels of BDNF and substance P have been found associated with increased itching in eczema.
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