13 Facts About Trimipramine

Trimipramine, sold under the brand name Surmontil among others, is a tricyclic antidepressant which is used to treat depression.

Trimipramine is said to be less epileptogenic than other TCAs, although seizures have still been reported in association with it.

Trimipramine should be administered with care in patients receiving therapy for hyperthyrodism.

Trimipramine is a very weak reuptake inhibitor of serotonin, norepinephrine, and dopamine, and unlike most other TCAs, has been claimed to be devoid of clinically significant monoamine reuptake inhibition.

Trimipramine is an antagonist of the H2 receptor with lower potency and has been found to be effective in the treatment of duodenal ulcers.

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Trimipramine is unique in that it is an exception and produces antidepressant effects without compromising or otherwise affecting REM sleep.

Trimipramine is a weak but significant antagonist of the dopamine D1 and D2 receptors, and binds to the D4 receptor.

Trimipramine is a tricyclic compound, specifically a dibenzazepine, and possesses three rings fused together with a side chain attached in its chemical structure.

Trimipramine is a derivative of imipramine with a methyl group added to its side chain and is known as 2'-methylimipramine or ß-methylimipramine.

Trimipramine is a tertiary amine TCA, with its side chain-demethylated metabolite desmethyltrimipramine being a secondary amine.

Trimipramine is the generic name of the drug and its INN, USAN, BAN, and DCF, while trimipramine maleate is its USAN, USP, BANM, and JAN.

Trimipramine is marketed throughout the world mainly under the brand name Surmontil.

Trimipramine is no longer marketed in Australia, though it was previously.