Agomelatine, sold under the brand names Valdoxan and Thymanax, among others, is an atypical antidepressant most commonly used to treat major depressive disorder.
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10 Facts About Agomelatine
3.
Agomelatine is used for the treatment of major depressive episodes in adults in Europe.
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4.
Agomelatine has been found more effective than placebo in the treatment of generalized anxiety disorder in a number of short-term double-blind placebo-controlled studies and in long term relapse prevention.
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5.
Agomelatine is contraindicated in patients with kidney or liver impairment.
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6.
Agomelatine induced an advance of the time of sleep onset and of minimum heart rate.
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7.
Agomelatine has no abuse potential as measured in healthy volunteer studies.
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8.
Agomelatine has shown an antidepressant-like effect in animal models of depression as well as in models with circadian rhythm desynchronisation and in models related to stress and anxiety.
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9.
Agomelatine was discovered and developed by the European pharmaceutical company Servier Laboratories Ltd.
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10.
Agomelatine has been investigated for its effects on sleep regulation due its actions as a melatonin receptor agonist.
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