12 Facts About Anandamide


Anandamide, known as N-arachidonoylethanolamine, is a fatty acid neurotransmitter.

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Anandamide was the first endocannabinoid to be discovered: it participates in the body's endocannabinoid system by binding to cannabinoid receptors, the same receptors that the psychoactive compound THC in cannabis acts on.

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Anandamide is found in nearly all tissues in a wide range of animals.

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Anandamide has been found in plants, including small amounts in chocolate.

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Anandamide is derived from the non-oxidative metabolism of arachidonic acid, an essential omega-6 fatty acid.

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Anandamide was first described in 1992 by Raphael Mechoulam and his lab members W A Devane and Lumir Hanus.

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Anandamide is important for implantation of the early stage embryo in its blastocyst form into the uterus.

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Anandamide is the precursor of a class of physiologically active substances, the prostamides.

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Anandamide was found in 2007 to inhibit the proliferation of certain human breast cancer cell lines in vitro.

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Anandamide is found in chocolate together with two substances that might mimic the effects of anandamide, N-oleoylethanolamine and N-linoleoylethanolamine.

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Anandamide has been shown to impair working memory in rats, while THC shows a deficit in working memory.

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Anandamide injected directly into the forebrain reward-related brain structure nucleus accumbens enhances the pleasurable responses of rats to a rewarding sucrose taste, and enhances food intake as well.

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