12 Facts About Anandamide

Anandamide, known as N-arachidonoylethanolamine, is a fatty acid neurotransmitter.

Anandamide was the first endocannabinoid to be discovered: it participates in the body's endocannabinoid system by binding to cannabinoid receptors, the same receptors that the psychoactive compound THC in cannabis acts on.

Anandamide is found in nearly all tissues in a wide range of animals.

Anandamide has been found in plants, including small amounts in chocolate.

Anandamide is derived from the non-oxidative metabolism of arachidonic acid, an essential omega-6 fatty acid.

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Anandamide was first described in 1992 by Raphael Mechoulam and his lab members W A Devane and Lumir Hanus.

Anandamide is important for implantation of the early stage embryo in its blastocyst form into the uterus.

Anandamide is the precursor of a class of physiologically active substances, the prostamides.

Anandamide was found in 2007 to inhibit the proliferation of certain human breast cancer cell lines in vitro.

Anandamide is found in chocolate together with two substances that might mimic the effects of anandamide, N-oleoylethanolamine and N-linoleoylethanolamine.

Anandamide has been shown to impair working memory in rats, while THC shows a deficit in working memory.

Anandamide injected directly into the forebrain reward-related brain structure nucleus accumbens enhances the pleasurable responses of rats to a rewarding sucrose taste, and enhances food intake as well.