14 Facts About BRCA gene

BRCA gene1 combines with other tumor suppressors, DNA damage sensors and signal transducers to form a large multi-subunit protein complex known as the BRCA gene1-associated genome surveillance complex.

Four years later, after an international race to find it, the BRCA gene was cloned in 1994 by scientists at University of Utah, National Institute of Environmental Health Sciences and Myriad Genetics.

Human BRCA1 gene is located on the long arm of chromosome 17 at region 2 band 1, from base pair 41,196,312 to base pair 41,277,500.

BRCA gene1 is part of a complex that repairs double-strand breaks in DNA.

BRCA gene1 is part of a protein complex that repairs DNA when both strands are broken.

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The double-strand repair mechanism in which BRCA gene1 participates is homology-directed repair, where the repair proteins copy the identical sequence from the intact sister chromatid.

BRCA gene1 is involved in another type of DNA repair, termed mismatch repair.

BRCA gene1 was shown to co-purify with the human RNA Polymerase II holoenzyme in HeLa extracts, implying it is a component of the holoenzyme.

Mutated BRCA1 gene usually makes a protein that does not function properly.

Women who have inherited a defective BRCA1 or BRCA2 gene are at a greatly elevated risk to develop breast and ovarian cancer.

In cells with over-expressed miR-182, BRCA gene1 remained low, even after exposure to ionizing radiation.

Since BRCA gene1 is a key DNA repair protein, these findings suggest that naturally occurring DNA damages in oocytes are repaired less efficiently in women with a BRCA gene1 defect, and that this repair inefficiency leads to early reproductive failure.

However, the Court held that manipulation of a BRCA gene to create something not found in nature could still be eligible for patent protection.

BRCA gene1 has been shown to interact with the following proteins:.