19 Facts About Bupropion

Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation.

Bupropion does carry a much higher risk of seizure than many other antidepressants and extreme caution must be taken in patients with a history of seizure disorder.

Bupropion was invented by Nariman Mehta, who worked at Burroughs Wellcome, in 1969.

Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000.

Bupropion improves depression in bipolar disorder, with the efficacy and risk of affective switch being similar to other antidepressants.

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Bupropion treatment is not associated with weight gain; on the contrary, the majority of studies observed significant weight loss in bupropion-treated participants.

Bupropion is more effective than selective serotonin reuptake inhibitors at improving symptoms of hypersomnia and fatigue in depressed patients.

Bupropion, when used for treating obesity over a period of 6 to 12 months, results in an average weight loss of 2.

Bupropion is not effective in the treatment of cocaine dependence, but it is showing promise in reducing drug use in light methamphetamine users.

Bupropion is not effective in treating chronic low back pain.

Bupropion is available as an oral tablet in a number of different formulations.

Bupropion has the highest incidence of insomnia of all second-generation antidepressants, apart from desvenlafaxine.

Bupropion has rarely been associated with instances of Stevens–Johnson syndrome.

Bupropion has been found to increase levels of atomoxetine by 5.

Bupropion lowers the seizure threshold, and therefore can potentially interact with other medications that lower it, such as antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids.

Bupropion has no meaningful direct activity at a variety of receptors, including a- and ß-adrenergic, dopamine, serotonin, histamine, and muscarinic acetylcholine receptors.

Bupropion is metabolized in the body by a variety of pathways.

Bupropion is an aminoketone that belongs to the class of substituted cathinones and the more general class of substituted phenethylamines.

Bupropion was invented by Nariman Mehta of Burroughs Wellcome in 1969, and the US patent for it was granted in 1974.