Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant.
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14 Facts About Clomipramine
2.
Clomipramine was discovered in 1964 by the Swiss drug manufacturer Ciba-Geigy.
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3.
Clomipramine has a number of uses in medicine including in the treatment of:.
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4.
Clomipramine is distributed in breast milk and hence nursing while taking clomipramine is advised against.
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5.
Clomipramine is a reuptake inhibitor of serotonin and norepinephrine, or a serotonin–norepinephrine reuptake inhibitor; that is, it blocks the reuptake of these neurotransmitters back into neurons by preventing them from interacting with their transporters, thereby increasing their extracellular concentrations in the synaptic cleft and resulting in increased serotonergic and noradrenergic neurotransmission.
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6.
Clomipramine was the first drug that was investigated for and found to be effective in the treatment of OCD.
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7.
Clomipramine is a tricyclic compound, specifically a dibenzazepine, and possesses three rings fused together with a side chain attached in its chemical structure.
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8.
Clomipramine is a derivative of imipramine with a chlorine atom added to one of its rings and is known as 3-chloroimipramine.
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9.
Clomipramine was developed by Geigy as a chlorinated derivative of Imipramine.
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10.
Clomipramine was eventually approved in the United States for the treatment of OCD in 1989 and became available in 1990.
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11.
Clomipramine is the only TCA that has been shown to be effective in the treatment of OCD and that is approved by the FDA for the treatment of OCD; the other TCAs failed clinical trials for this indication, likely due to insufficient serotonergic activity.
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12.
Clomipramine is the English and French generic name of the drug and its INN, BAN, and DCF, while clomipramine hydrochloride is its USAN, USP, BANM, and JAN.
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13.
Clomipramine is marketed throughout the world mainly under the brand names Anafranil and Clomicalm for use in humans and animals, respectively.
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14.
Clomipramine has demonstrated efficacy in treating urine spraying in cats.
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