15 Facts About Imipramine

Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant mainly used in the treatment of depression.

Imipramine appears to work by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors.

Imipramine was discovered in 1951 and was introduced for medical use in 1957.

Imipramine is used in the treatment of depression and certain anxiety disorders.

Imipramine is available in the form of oral tablets and capsules.

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Imipramine affects numerous neurotransmitter systems known to be involved in the etiology of depression, anxiety, attention-deficit hyperactivity disorder, enuresis and numerous other mental and physical conditions.

Imipramine is similar in structure to some muscle relaxants, and has a significant analgesic effect and, thus, is very useful in some pain conditions.

Imipramine is a tricyclic compound, specifically a dibenzazepine, and possesses three rings fused together with a side chain attached in its chemical structure.

Imipramine is a tertiary amine TCA, with its side chain-demethylated metabolite desipramine being a secondary amine.

Imipramine was first tried for treating psychotic disorders such as schizophrenia, but proved ineffective.

Imipramine has additional indications for the treatment of panic attacks, chronic pain, and Kleine-Levin syndrome.

Imipramine is the English and French generic name of the drug and its INN, BAN, and DCF, while imipramine hydrochloride is its USAN, USP, BANM, and JAN.

Imipramine is marketed throughout the world mainly under the brand name Tofranil.

Imipramine pamoate is marketed under the brand name Tofranil-PM for intramuscular injection.

Imipramine is available for medical use widely throughout the world, including in the United States, the United Kingdom, elsewhere in Europe, India, Brazil, South Africa, Australia, and New Zealand.